From Theo Padnos: “The thing about life in an electricity-less cell underground is that you soon lose your orientation in time and space. Sometimes you wake up in the early evening believing it to be dawn. Winter couldn’t possibly have come yet, you tell yourself, and then one day, some chance glimpse of the out-of-doors reveals the snow to be sifting down over a courtyard. One’s captors do everything in their power to deepen this disorientation. Whenever you most need to see, that’s when they put you in a blindfold. You’re not meant to know the date, who’s winning the war, where you are, anyone’s actual names. During my time in Syria, I sustained a series of head injuries. Under such circumstances, the more one stares at the walls, the more the room spins. Which way is the floor? Off which walls is the gunfire ricocheting? You can guess, but really you have no idea.”
Weight-loss drugs like Ozempic work, but not in the way scientists originally thought they did
From The Atlantic: “When scientists first created the class of drugs that includes Ozempic, they told a tidy story about how the medications would work: The gut releases a hormone called GLP-1 that signals you’re full, so a drug that mimics GLP-1 could do the exact same thing, helping people eat less and lose weight. The rest, as they say, is history. The GLP-1 revolution birthed semaglutide, which became Ozempic and Wegovy, and tirzepatide, which became Mounjaro and Zepbound—drugs that are rapidly changing the face of obesity medicine. They work as intended: as modulators of appetite. But at the same time that they have become massive successes, the science that underpinned their development has fallen apart. The fact that they worked was serendipity, Randy Seeley, an obesity researcher at the University of Michigan, told me.”
Note: This is a version of my personal newsletter, which I send out via Ghost, the open-source publishing platform. You can see other issues and sign up here.
Continue reading “What it was like to spend two years as a hostage in Syria”