
From Atlas Obscura: “In 1997 — at the height of a wave of exposés, lawsuits, and public outrage against the tobacco industry — a man named Puzant Torigian, a Hackensack, New Jersey-based entrepreneur, launched a new brand of cigarettes called Bravo. Bravo cigarettes contained nothing but lettuce, dried and cured to look like tobacco, processed into sheets, shredded, flavored with herbal extracts, and rolled up and boxed like any other cig. Torigian’s marketing materials claimed that Bravo “tastes (well pretty close) like a cigarette,” but lacked their harmful nicotine and tobacco tar. However, in interviews, he stressed that he hadn’t spent 40 years developing the product just to offer a safer replacement for traditional smokes. He wanted people to use Bravo as a smoking cessation tool. Even at the time, this struck many folks as an odd proposition. But Bravo wasn’t just one aging inventor’s offbeat idea. It was the most developed of many attempts, stretching back over a century, to develop alternatives to tobacco cigarettes.”
An unlikely organ helps to explain Sherpas’ aptitude for altitude

From Scientific American: “For most mountaineers, some level of altitude sickness is inevitable. But Indigenous highlanders living on the Tibetan Plateau, known as Sherpas, have inhabited the high Himalaya long enough to have an evolutionary edge at tolerating elevation compared with lowlanders born and raised farther down. For a study in the Proceedings of the National Academy of Sciences USA, researchers compared Sherpa and lowlander blood samples during a Himalayan trek to investigate the Sherpas’ aptitude for altitude—and they found a crucial clue in the kidney.The thinner atmosphere up high can lead to hypoxia, a dangerous lack of oxygen. Hypoxic people breathe faster to bring more oxygen into their lungs. But extra breathing also empties the lungs of more carbon dioxide than usual, which in turn reduces the production of carbonic acid in the blood. Once blood acidity shifts, the only thing that can fix it is the kidneys.”
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