{"id":282276,"date":"2025-11-24T09:37:00","date_gmt":"2025-11-24T14:37:00","guid":{"rendered":"https:\/\/mathewingram.com\/work\/?p=282276"},"modified":"2025-11-24T09:22:59","modified_gmt":"2025-11-24T14:22:59","slug":"she-got-colon-cancer-at-21-but-her-identical-twin-did-not","status":"publish","type":"post","link":"https:\/\/mathewingram.com\/work\/2025\/11\/24\/she-got-colon-cancer-at-21-but-her-identical-twin-did-not\/","title":{"rendered":"She got colon cancer at 21 but her identical twin did not"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full is-resized\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"525\" height=\"353\" data-attachment-id=\"282277\" data-permalink=\"https:\/\/mathewingram.com\/work\/2025\/11\/24\/she-got-colon-cancer-at-21-but-her-identical-twin-did-not\/image-91-1\/\" data-orig-file=\"https:\/\/i0.wp.com\/mathewingram.com\/work\/wp-content\/uploads\/2025\/11\/image-91-1.png?fit=819%2C550&amp;ssl=1\" data-orig-size=\"819,550\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"image-91-1\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/mathewingram.com\/work\/wp-content\/uploads\/2025\/11\/image-91-1.png?fit=525%2C353&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/mathewingram.com\/work\/wp-content\/uploads\/2025\/11\/image-91-1.png?resize=525%2C353&#038;ssl=1\" alt=\"\" class=\"wp-image-282277\" style=\"width:900px\" srcset=\"https:\/\/i0.wp.com\/mathewingram.com\/work\/wp-content\/uploads\/2025\/11\/image-91-1.png?w=819&amp;ssl=1 819w, https:\/\/i0.wp.com\/mathewingram.com\/work\/wp-content\/uploads\/2025\/11\/image-91-1.png?resize=300%2C201&amp;ssl=1 300w, https:\/\/i0.wp.com\/mathewingram.com\/work\/wp-content\/uploads\/2025\/11\/image-91-1.png?resize=768%2C516&amp;ssl=1 768w\" sizes=\"auto, (max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Brinlee Luster brushed off the exhaustion and stomach cramps as stress. She was finishing college, planning a wedding, and racing toward graduation. At first, the changes were easy to dismiss. A cold that wouldn&#8217;t clear up. An unsettled, uncomfortable feeling in her gut that could be anxiety. Feeling winded on an easy hike. But as the pain sharpened and she started leaving class 10 times to use the bathroom, she knew something was seriously wrong. Or more accurately, her sister did. Mariela Luster and Brinlee are identical twins who share everything together \u2014 attending the same college, in the same program, even meeting their husbands on the same day at the same community event. Mariela was the first to flag that Brinlee, normally energetic and enthusiastic, was not just under the weather. Doctors found a tumor so large it was blocking her colon. At 21, Brinlee was diagnosed with stage 4&nbsp;colon cancer. (<a href=\"https:\/\/www.businessinsider.com\/identical-twins-young-colon-cancer-diagnosis-2025-11\">via Business Insider<\/a>)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">This 101-year-old barista has been serving coffee in Italy for eighty years<\/h2>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/newsletter.mathewingram.com\/content\/images\/2025\/11\/image-89.png?w=525&#038;ssl=1\" alt=\"\" style=\"width:900px\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">From 7 in the morning until 7 in the evening, Anna Possi does what she&#8217;s been doing for more than 80 years, brewing espressos and serving coffees. She first did this sort of job at the end of World War II, when she went to work in her uncle&#8217;s restaurants. In 1958, Possi and her husband opened Bar Centrale in the small town of Nebiuno on the shores of Lake Maggiore in northern Italy. Since her husband died in 1974, she&#8217;s been on her own. I have customers who are now grandparents and come in with their grandchildren saying, Anna, do you remember when there was a dance floor outside, when there was a jukebox and pinball machines? Those were different times. Now they&#8217;re only memories. Possi plans to remain available. She has no intention of retiring. She&#8217;s among the growing number of Italians who are centenarians, the vast majority of them women. (<a href=\"https:\/\/www.pbs.org\/newshour\/show\/italys-oldest-barista-who-has-served-coffee-since-wwii-turns-101\">via PBS<\/a>)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Note<\/strong>: This is a version of my When The Going Gets Weird newsletter, which I send out via Ghost, the open-source publishing platform. You can\u00a0<a href=\"https:\/\/newsletter.mathewingram.com\/\">see other issues\u00a0and sign up here<\/a>.<\/em><\/p>\n\n\n\n<!--more-->\n\n\n\n<h2 class=\"wp-block-heading\">No one really knows who first developed aspirin<\/h2>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/newsletter.mathewingram.com\/content\/images\/2025\/11\/image-88.png?w=525&#038;ssl=1\" alt=\"\" style=\"width:900px\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">When I was in medical school in 2007, I learned that willow bark tea has been used for thousands of years to treat pain and fever. I\u2019ve read at least a handful of books \u2014 historical and fantasy alike \u2014 that make the same claim. Diarmuid Jeffreys wrote an entire book on aspirin,&nbsp;<em>The Remarkable Story of a Wonder Drug<\/em>, which detailed how willow was used from Ancient Egypt, through Ancient Greece and Rome, to the Middle Ages in Europe, and beyond. This is repeated by&nbsp;journal&nbsp;articles, though their claims are rarely referenced. These accounts seem plausible. Willow trees are relatively common,&nbsp;grow worldwide, and have had various uses since antiquity.&nbsp;However, there is a problem with the claim that willow bark and similar plants are the ancient equivalent of aspirin. And it is this: most of the extant evidence referenced by histories of aspirin fail entirely to mention using willow bark or similar plants to reduce fever, pain, or inflammation.&nbsp;(<a href=\"https:\/\/press.asimov.com\/articles\/aspirin\">via Asimov.com<\/a>)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Hi everyone! Mathew Ingram here. I am able to continue writing this newsletter in part because of your financial help and support, which you can do either <\/em><a href=\"https:\/\/mathewingram.com\/2t3\" target=\"_blank\" rel=\"noreferrer noopener\"><em>through my Patreon<\/em><\/a><em> or by upgrading your subscription to a monthly contribution. I enjoy gathering all of these links and sharing them with you, but it does take time, and your support makes it possible for me to do that. I also write a weekly newsletter of technology analysis called <\/em><a href=\"https:\/\/torment-nexus.mathewingram.com\"><em>The Torment Nexus<\/em><\/a><em>.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Beer makers often use a type of collagen made from the dried swim bladders of fish<\/h2>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/newsletter.mathewingram.com\/content\/images\/2025\/11\/image-87.png?w=525&#038;ssl=1\" alt=\"\" style=\"width:900px\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Isinglass is a form of&nbsp;collagen&nbsp;obtained from the dried&nbsp;swim bladders&nbsp;of&nbsp;fish. The English word origin is from the obsolete Dutch&nbsp;<em>huizenblaas<\/em>&nbsp;\u2013&nbsp;<em>huizen<\/em>&nbsp;is a kind of&nbsp;sturgeon, and&nbsp;<em>blaas<\/em>&nbsp;is a bladder. The bladders, once removed from the fish, processed, and dried, are formed into various shapes for use. It is used mainly for the&nbsp;clarification&nbsp;or fining of some&nbsp;beer&nbsp;and&nbsp;wine. It can also be cooked into a paste for specialised&nbsp;gluing&nbsp;purposes. Although originally made exclusively from sturgeon, especially&nbsp;beluga, in 1795 an invention by&nbsp;William Murdoch&nbsp;facilitated a cheap substitute using&nbsp;cod. This was extensively used in&nbsp;Britain&nbsp;in place of&nbsp;Russian&nbsp;isinglass, and in the US&nbsp;hake&nbsp;was important. In modern British brewing all commercial isinglass products are blends of material from a limited range of tropical fish. Before the inexpensive production of&nbsp;gelatin&nbsp;and other competing products, isinglass was used in confectionery and desserts such as fruit jelly and&nbsp;<em>blancmange<\/em>. (<a href=\"https:\/\/en.wikipedia.org\/wiki\/Isinglass\">via Wikipedia<\/a>)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">They were the first couple to drive into the Arctic Circle in 1903<\/h2>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/newsletter.mathewingram.com\/content\/images\/2025\/11\/image-90-1-1.png?w=525&#038;ssl=1\" alt=\"\" style=\"width:900px\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Early in the era of automobile travel, in 1903, Mr. and Mrs. Charles Glidden were the first people to drive a motorcar into the Arctic Circle, the area of land near the North Pole defined by the fact that inside it the sun does not rise at all during the winter solstice. They traveled in summer, leaving their home in Boston in June of that year with plans to road trip through Ireland, England, Wales, Denmark, and Norway. On July 16 the car was was loaded on a steamer to from London to Copenhagen. There began complications that give us insight into the early days of motor rambles. A cable informed Mr Glidden that \u201ctwo of the Governors of Norwegian provinces had canceled the permits granted, and others had added restrictions.\u201d In one case, a governor required that \u201ca man on horseback should precede the car, warning the populace of its coming and clearing the way, although the speed limit is only fifteen miles an hour.\u201d Understandably, Mr. Glidden decided to avoid Norway. (<a href=\"https:\/\/vicarioustravel.substack.com\/p\/the-first-couple-to-drive-into-the\">via Vicarious Travel<\/a>)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Hey babe, the Austrians are doing that whole demonic Krampus thing again<\/h2>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/x.com\/cinecitta2030\/status\/1992247022934794271\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/newsletter.mathewingram.com\/content\/images\/2025\/11\/image-92.png?w=525&#038;ssl=1\" alt=\"\"\/><\/a><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Acknowledgements<\/strong><\/em><em>: I find a lot of these links myself, but I also get some from other newsletters that I rely on as &#8220;serendipity engines,&#8221; such as&nbsp;<\/em><a href=\"https:\/\/themorningnews.org\/?ref=newsletter.mathewingram.com\"><em>The Morning News<\/em><\/a><em>&nbsp;from Rosecrans Baldwin and Andrew Womack, Jodi Ettenberg&#8217;s&nbsp;<\/em><a href=\"https:\/\/jodiettenberg.substack.com\/?ref=newsletter.mathewingram.com\"><em>Curious About Everything<\/em><\/a><em>, Dan Lewis&#8217;s&nbsp;<\/em><a href=\"https:\/\/nowiknow.com\/?ref=newsletter.mathewingram.com\"><em>Now I Know<\/em><\/a><em>, Robert Cottrell and Caroline Crampton&#8217;s&nbsp;<\/em><a href=\"https:\/\/thebrowser.com\/?ref=newsletter.mathewingram.com\"><em>The Browser<\/em><\/a><em>, Clive Thompson&#8217;s&nbsp;<\/em><a href=\"https:\/\/buttondown.email\/clivethompson?ref=newsletter.mathewingram.com\"><em>Linkfest<\/em><\/a><em>, Noah Brier and Colin Nagy&#8217;s&nbsp;<\/em><a href=\"https:\/\/whyisthisinteresting.substack.com\/?ref=newsletter.mathewingram.com\"><em>Why Is This Interesting<\/em><\/a><em>, Maria Popova&#8217;s&nbsp;<\/em><a href=\"https:\/\/www.themarginalian.org\/?ref=newsletter.mathewingram.com\"><em>The Marginalian<\/em><\/a><em>, Sheehan Quirke AKA&nbsp;<\/em><a href=\"https:\/\/culturaltutor.com\/areopagus?ref=newsletter.mathewingram.com\"><em>The Cultural Tutor<\/em><\/a><em>, the&nbsp;<\/em><a href=\"https:\/\/www.smithsonianmag.com\/?ref=newsletter.mathewingram.com\"><em>Smithsonian<\/em><\/a><em>&nbsp;magazine, and&nbsp;<\/em><a href=\"https:\/\/daily.jstor.org\/?ref=newsletter.mathewingram.com\"><em>JSTOR Daily<\/em><\/a>.<em>&nbsp;If you come across something interesting that you think should be included here, please feel free to&nbsp;email me at mathew @ mathewingram dot com<\/em><\/p>\n<div class=\"syndication-links\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Brinlee Luster brushed off the exhaustion and stomach cramps as stress. She was finishing college, planning a wedding, and racing toward graduation. At first, the changes were easy to dismiss. A cold that wouldn&#8217;t clear up. An unsettled, uncomfortable feeling in her gut that could be anxiety. Feeling winded on an easy hike. But as &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/mathewingram.com\/work\/2025\/11\/24\/she-got-colon-cancer-at-21-but-her-identical-twin-did-not\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;She got colon cancer at 21 but her identical twin did not&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_crsspst_to_mathewingramblogwordpresscom":false,"mf2_syndication":[],"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[20],"tags":[],"class_list":["post-282276","post","type-post","status-publish","format-standard","hentry","category-newsletters"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/mathewingram.com\/work\/wp-json\/wp\/v2\/posts\/282276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mathewingram.com\/work\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mathewingram.com\/work\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mathewingram.com\/work\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mathewingram.com\/work\/wp-json\/wp\/v2\/comments?post=282276"}],"version-history":[{"count":1,"href":"https:\/\/mathewingram.com\/work\/wp-json\/wp\/v2\/posts\/282276\/revisions"}],"predecessor-version":[{"id":282278,"href":"https:\/\/mathewingram.com\/work\/wp-json\/wp\/v2\/posts\/282276\/revisions\/282278"}],"wp:attachment":[{"href":"https:\/\/mathewingram.com\/work\/wp-json\/wp\/v2\/media?parent=282276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mathewingram.com\/work\/wp-json\/wp\/v2\/categories?post=282276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mathewingram.com\/work\/wp-json\/wp\/v2\/tags?post=282276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}